Blood group O may be protective against and blood group A may render patients more susceptible to, respiratory failure in Covid-19 infection

During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci with Covid-19–induced respiratory failure. The findings confirm potential involvement of the ABO blood-group system

In this group of patient studied, a blood-group–specific analysis showed a higher risk of severe disease complication (respiratory failure) in blood group A than in other blood groups and a protective effect in blood group O as compared with other blood groups.

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COVID-19: Virus in Semen

By Kelly Young

Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS

Have a look at some of the latest developments in novel coronavirus disease (COVID-19):

Virus detected in semen: SARS-CoV-2 has been detected in the semen of men with COVID-19, according to findings in JAMA Network Open. Thirty-eight men with confirmed illness in China provided a semen sample for testing. Samples from 6 of the men (16%) tested positive for the virus; four of the men were in the acute stage of infection and two were in the recovery phase. The authors note that it is not yet known whether the virus can be transmitted sexually.

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Plaquenil = hydroxychloroquine

Hydroxychloroquine: Use of hydroxychloroquine is not associated with reduced risk for intubation or death among hospitalized COVID-19 patients, according to an observational study in the New England Journal of Medicine. Among nearly 1400 consecutive patients with COVID-19 in New York hospitals, researchers compared outcomes between those who received hydroxychloroquine and those who did not. After multivariable adjustment, the risk for the composite outcome of intubation or death was similar between the groups during a median follow-up of 23 days. (NEJM)

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Chilblains / “frostbites” & coronavirus infection

‘Frostbite’ toes and other peculiar rashes may be signs of coronavirus infection
Doctors recommend those with symptoms consider consulting a doctor, getting tested for the virus and self-isolation.

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Keep seeing your dermatologist during COVID-19

In response to the COVID-19 situation, dermatologists have adapted their practices to provide a safe environment for patients. Many are providing care via telehealth, using phone and videoconferencing. Most dermatology practices remain open, continuing to provide quality specialist dermatology care, whilst implementing strict infection control measures to ensure that the risks of coming into contact with the virus are extremely low.
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Something good has to come out of this…

Parking is much better for our patients ! Both in Hurstville (02 9580 1311) and Menai (02 9532 1166). Yes, I run a dermatology clinic on the 1st floor of Menai Marketplace every Thursday afternoon.

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Happy Easter (nonetheless) ! We’ll be back on Wednesday April 15th. See you then.

”Social distancing” in practice
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April 6-10 schedule

We are operating in Hurstville on Monday and Thursday for the week before Easter.

(02) 9580-1311

Thank you.

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Be safe : Wear your mask and Wash your hands.

We are still working but in restricted hours. We are here today, Monday and will return this Thursday, April 2nd. 2020.

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Roaccutane (isotretinoin) and depression

“According to an analysis published in JAMA Dermatology, from 1997 to 2017, nearly 18,000 cases of depression, anxiety, and emotional lability linked to isotretinoin use were reported to the U.S. Food and Drug Administration. Those in the 10- to 19-year-old age group accounted for the larger proportion of suicides — more than individuals in their 20s or 30s (58% vs. 37% vs. 4%). This suggests that teenagers may be “particularly vulnerable to psychiatric adverse events while taking isotretinoin,” or that they are prescribed the medication more frequently, noted the study authors. The majority of individuals to die from suicide were men (79%), which is consistent with national statistics.”

Meaning… For a group in which everyone is taking Roaccutane, aged from 10-30 years, the 10-19 years of age group is more prone to psychiatric events (depression, anxiety and emotional lability). We do not know if this is due to either taking Roaccutane or being 10-19 years of age or both.

However, the suicide rate among those taking isotretinoin may be lower than in the general population. In 2009 and 2010, respectively, 8.4 and 5.6 suicides occurred for every 100,000 individuals taking isotretinoin, which was lower than national rates from the same time period (11.8 and 12.1 per 100,000). The study’s lead author noted that a risk of increased suicidal ideation in patients with acne has been reported in prior studies, irrespective of treatment method.

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