During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci with Covid-19–induced respiratory failure. The findings confirm potential involvement of the ABO blood-group system
In this group of patient studied, a blood-group–specific analysis showed a higher risk of severe disease complication (respiratory failure) in blood group A than in other blood groups and a protective effect in blood group O as compared with other blood groups.
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Have a look at some of the latest developments in novel coronavirus disease (COVID-19):
Virus detected in semen: SARS-CoV-2 has been detected in the semen of men with COVID-19, according to findings in JAMA Network Open. Thirty-eight men with confirmed illness in China provided a semen sample for testing. Samples from 6 of the men (16%) tested positive for the virus; four of the men were in the acute stage of infection and two were in the recovery phase. The authors note that it is not yet known whether the virus can be transmitted sexually.
Hydroxychloroquine: Use of hydroxychloroquine is not associated with reduced risk for intubation or death among hospitalized COVID-19 patients, according to an observational study in the New England Journal of Medicine. Among nearly 1400 consecutive patients with COVID-19 in New York hospitals, researchers compared outcomes between those who received hydroxychloroquine and those who did not. After multivariable adjustment, the risk for the composite outcome of intubation or death was similar between the groups during a median follow-up of 23 days. (NEJM)
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“According to an analysis published in JAMA Dermatology, from 1997 to 2017, nearly 18,000 cases of depression, anxiety, and emotional lability linked to isotretinoin use were reported to the U.S. Food and Drug Administration. Those in the 10- to 19-year-old age group accounted for the larger proportion of suicides — more than individuals in their 20s or 30s (58% vs. 37% vs. 4%). This suggests that teenagers may be “particularly vulnerable to psychiatric adverse events while taking isotretinoin,” or that they are prescribed the medication more frequently, noted the study authors. The majority of individuals to die from suicide were men (79%), which is consistent with national statistics.”
Meaning… For a group in which everyone is taking Roaccutane, aged from 10-30 years, the 10-19 years of age group is more prone to psychiatric events (depression, anxiety and emotional lability). We do not know if this is due to either taking Roaccutane or being 10-19 years of age or both.
However, the suicide rate among those taking isotretinoin may be lower than in the general population. In 2009 and 2010, respectively, 8.4 and 5.6 suicides occurred for every 100,000 individuals taking isotretinoin, which was lower than national rates from the same time period (11.8 and 12.1 per 100,000). The study’s lead author noted that a risk of increased suicidal ideation in patients with acne has been reported in prior studies, irrespective of treatment method.